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Download ebook Myocardial Ischemia and Preconditioning

Download ebook Myocardial Ischemia and Preconditioning

Myocardial Ischemia and Preconditioning by Naranjan S. Dhalla
Myocardial Ischemia and Preconditioning
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Author: Naranjan S. Dhalla
Number of Pages: 558 pages
Published Date: 01 Jan 2003
Publisher: Kluwer Academic Publishers
Publication Country: Boston, MA, United States
Language: Englishhttps://d39ttiideeq0ys.cloudfront.net/assets/images/book/large/9781/4613/9781461350361.jpg
ISBN: 9781402071959
File size: 30 Mb
Download Link: myocardial ischemia and preconditioning
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Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps is now in its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.

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